Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0 ± 6.6% (mean ± SD) in freshly-isolated human NK-cells (FI-NK) and 83.4 ± 10.1...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Colamartino, Aurelien B. L., Lemieux, William, Bifsha, Panojot, Nicoletti, Simon, Chakravarti, Nitin, Sanz, Joaquín, Roméro, Hugo, Selleri, Silvia, Béland, Kathie, Guiot, Mélanie, Tremblay-Laganière, Camille, Dicaire, Renée, Barreiro, Luis, Lee, Dean A., Verhoeyen, Els, Haddad, Elie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927467/
https://ncbi.nlm.nih.gov/pubmed/31921138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02873
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