Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0 ± 6.6% (mean ± SD) in freshly-isolated human NK-cells (FI-NK) and 83.4 ± 10.1...

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Main Authors: Aurelien B. L. Colamartino, William Lemieux, Panojot Bifsha, Simon Nicoletti, Nitin Chakravarti, Joaquín Sanz, Hugo Roméro, Silvia Selleri, Kathie Béland, Mélanie Guiot, Camille Tremblay-Laganière, Renée Dicaire, Luis Barreiro, Dean A. Lee, Els Verhoeyen, Elie Haddad
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-12-01
Colecção:Frontiers in Immunology
Assuntos:
NK-cell transduction
baboon retrovirus envelope pseudotyped lentivectors
chimeric antigen receptor
NK amplification and expansion system (NKAES)
cytotoxicity
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.02873/full
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