An Allosteric Pathway in Copper, Zinc Superoxide Dismutase Unravels the Molecular Mechanism of the G93A Amyotrophic Lateral Sclerosis-Linked Mutation

[Image: see text] Several different mutations of the protein copper, zinc superoxide dismutase (SOD1) produce the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). The molecular mechanism by which the diverse mutations converge to a similar pathology is currently unknown. The electrost...

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Veröffentlicht in:J Phys Chem Lett
Hauptverfasser: Souza, Paulo C. T., Thallmair, Sebastian, Marrink, Siewert J., Mera-Adasme, Raúl
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926953/
https://ncbi.nlm.nih.gov/pubmed/31747286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.9b02868
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