WASP Restricts Active Rac to Maintain Cells’ Front-Rear Polarization

Efficient motility requires polarized cells, with pseudopods at the front and a retracting rear. Polarization is maintained by restricting the pseudopod catalyst, active Rac, to the front. Here, we show that the actin nucleation-promoting factor Wiskott-Aldrich syndrome protein (WASP) contributes to...

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Gepubliceerd in:Curr Biol
Hoofdauteurs: Amato, Clelia, Thomason, Peter A., Davidson, Andrew J., Swaminathan, Karthic, Ismail, Shehab, Machesky, Laura M., Insall, Robert H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926487/
https://ncbi.nlm.nih.gov/pubmed/31786060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.10.036
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