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Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

Protein multivalency can provide increased affinity and specificity relative to monovalent counterparts, but these emergent biochemical properties and their mechanistic underpinnings are difficult to predict as a function of the biophysical properties of the multivalent binding partners. Here, we pr...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Errington, Wesley J., Bruncsics, Bence, Sarkar, Casim A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926015/
https://ncbi.nlm.nih.gov/pubmed/31776263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902909116
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