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NAD hydrolysis by the tuberculosis necrotizing toxin induces lethal oxidative stress in macrophages
Mycobacterium tuberculosis (Mtb) kills infected macrophages through necroptosis, a programmed cell death that enhances mycobacterial replication and dissemination. The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of Mtb in macrophages and induces necroptosis by NAD(+) hydrol...
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| Publié dans: | Cell Microbiol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925628/ https://ncbi.nlm.nih.gov/pubmed/31509891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.13115 |
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