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Quantitative Prediction of CYP3A4 and CYP3A5-Mediated Drug Interactions
We verified a physiologically-based pharmacokinetic (PBPK) model to predict cytochrome P450 3A4/5-mediated drug-drug interactions (DDIs). A midazolam-ketoconazole interaction study in 24 subjects selected by CYP3A5 genotype, and LC/MS-quantification of CYP3A4/5 abundance from independently acquired...
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| Pubblicato in: | Clin Pharmacol Ther |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925622/ https://ncbi.nlm.nih.gov/pubmed/31356678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1596 |
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