Quantitative Prediction of CYP3A4 and CYP3A5-Mediated Drug Interactions

We verified a physiologically-based pharmacokinetic (PBPK) model to predict cytochrome P450 3A4/5-mediated drug-drug interactions (DDIs). A midazolam-ketoconazole interaction study in 24 subjects selected by CYP3A5 genotype, and LC/MS-quantification of CYP3A4/5 abundance from independently acquired...

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Publicado en:Clin Pharmacol Ther
Autores principales: Guo, Yingying, Lucksiri, Aroonrut, Dickinson, Gemma L., Vuppalanchi, Raj K., Hilligoss, Janna K., Hall, Stephen D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925622/
https://ncbi.nlm.nih.gov/pubmed/31356678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1596
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