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Development of a chemical toolset for studying the paralog-specific function of IRE1
The dual kinase endoribonuclease IRE1 is a master regulator of cell fate decisions in cells experiencing endoplasmic reticulum (ER) stress. In mammalian cells there are two paralogs of IRE1: IRE1α and IRE1β. While IRE1α has been extensively studied, much less is understood about IRE1β and its role i...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925334/ https://ncbi.nlm.nih.gov/pubmed/31609569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00482 |
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