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Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

In skeletal muscles, calorie restriction (CR) preserves muscle mass in middle-aged rats but not younger rats. The underlying mechanisms for this age-specific response are unknown. Skeletal muscle mass depends on several factors, with protein synthesis and degradation playing major roles. Therefore,...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Chen, Chiao-Nan, Liao, Yi-Hung, Tsai, Shiow-Chwen, Thompson, LaDora V.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925080/
https://ncbi.nlm.nih.gov/pubmed/31676964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00109-8
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