Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling

Renal fibrosis contributes to declining renal function in the elderly. What is unclear however, is whether epithelial-mesenchymal transition (EMT) contributes to this age-related renal fibrosis. Here, we analyzed indicators of EMT during kidney aging and investigated the protective effects and mecha...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Dong, Dan, Cai, Guang-yan, Ning, Yi-chun, Wang, Jing-chao, Lv, Yang, Hong, Quan, Cui, Shao-yuan, Fu, Bo, Guo, Ya-nan, Chen, Xiang-mei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper: Gerotarget (Focus on Aging)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369951/
https://ncbi.nlm.nih.gov/pubmed/28147330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14884
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