Pharmacological inhibition of the MEK5/ERK5 and PI3K/Akt signaling pathways synergistically reduces viability in triple-negative breast cancer

Triple-negative breast cancers (TNBCs) represent 15–20% of all breast cancers and are often associated with poor prognosis. The lack of targeted therapies for TNBCs contributes to higher mortality rates. Aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK)...

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Veröffentlicht in:J Cell Biochem
Hauptverfasser: Wright, Thomas D, Raybuck, Christopher, Bhatt, Akshita, Monlish, Darlene, Chakrabarty, Suravi, Wendekier, Katy, Gartland, Nathan, Gupta, Mohit, Burow, Matthew E, Flaherty, Patrick T, Cavanaugh, Jane E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923606/
https://ncbi.nlm.nih.gov/pubmed/31464004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.29350
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