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Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein degradation and is often seriously disruptive to biological systems. Deamidation has been shown to negatively affect both in vitro stability and in vivo biological...
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| Pubblicato in: | Mol Ther Methods Clin Dev |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Gene & Cell Therapy
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6923510/ https://ncbi.nlm.nih.gov/pubmed/31890727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.09.008 |
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