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Harnessing DNA Double-Strand Break Repair for Cancer Treatment
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher DSB burden due to oncogene-induced replication stress and acquired defects in DNA damage response (DDR) mechanisms. Conse...
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| Vydáno v: | Front Oncol |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6921965/ https://ncbi.nlm.nih.gov/pubmed/31921645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01388 |
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