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Task-evoked substantia nigra hyperactivity associated with prefrontal hypofunction, prefrontonigral disconnectivity and nigrostriatal connectivity predicting psychosis severity in medication naïve first episode schizophrenia

The widely cited prefrontal dysfunction – excess subcortical dopamine model of schizophrenia posits that prefrontal deficits give rise to cognitive impairments and the disinhibition of subcortical dopamine release underlying psychosis. While this has been one of the most influential schizophrenia mo...

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Detalhes bibliográficos
Publicado no:Schizophr Res
Main Authors: Yoon, Jong H., Westphal, Andrew J., Minzenberg, Michael J., Niendam, Tara, Ragland, J. Daniel, Lesh, Tyler, Solomon, Marjorie, Carter, Cameron S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921934/
https://ncbi.nlm.nih.gov/pubmed/25266549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2014.09.022
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