Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans

BACKGROUND: Melatonin has been described in the literature as a potent antioxidant. However, melatonin presents variable, low bioavailability and a short half-life. The use of polymeric nanoparticulated systems has been proposed for controlled release. Thus, the purpose of this study was to investig...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Charão, Mariele F., Goethel, Gabriela, Brucker, Natália, Paese, Karina, Eifler-Lima, Vera L., Pohlmann, Adriana R., Guterres, Silvia S., Garcia, Solange C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921496/
https://ncbi.nlm.nih.gov/pubmed/31852511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-019-0352-4
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