Genotype-free demultiplexing of pooled single-cell RNA-seq

A variety of methods have been developed to demultiplex pooled samples in a single cell RNA sequencing (scRNA-seq) experiment which either require hashtag barcodes or sample genotypes prior to pooling. We introduce scSplit which utilizes genetic differences inferred from scRNA-seq data alone to demu...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Xu, Jun, Falconer, Caitlin, Nguyen, Quan, Crawford, Joanna, McKinnon, Brett D., Mortlock, Sally, Senabouth, Anne, Andersen, Stacey, Chiu, Han Sheng, Jiang, Longda, Palpant, Nathan J., Yang, Jian, Mueller, Michael D., Hewitt, Alex W., Pébay, Alice, Montgomery, Grant W., Powell, Joseph E., Coin, Lachlan J.M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921391/
https://ncbi.nlm.nih.gov/pubmed/31856883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1852-7
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