Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway

BACKGROUND: Metastasis of rhabdomyosarcoma (RMS) is the primary cause of tumour-related deaths. Previous studies have shown that overexpression of the guanine nucleotide exchange factor T (GEFT) is correlated with a poorer RMS prognosis, but the mechanism remains largely unexplored. METHODS: We focu...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Chunxia, Zhang, Liang, Cui, Wenwen, Du, Juan, Li, Zhenzhen, Pang, Yuwen, Liu, Qianqian, Shang, Hao, Meng, Lian, Li, Wanyu, Song, Lingxie, Wang, Ping, Xie, Yuwen, Wang, Yuanyuan, Liu, Yang, Hu, Jianming, Zhang, Wenjie, Li, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921210/
https://ncbi.nlm.nih.gov/pubmed/31761617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.060
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