Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin

BACKGROUND: Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death during childhood. Due to their diffuse growth characteristics, chemoresistance and location behind the blood-brain barrier (BBB), the prognosis of pHGG has barely improved in the past decades. As such, ther...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Metselaar, Dennis S., Meel, Michaël H., Benedict, Bente, Waranecki, Piotr, Koster, Jan, Kaspers, Gertjan J.L., Hulleman, Esther
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921187/
https://ncbi.nlm.nih.gov/pubmed/31735550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.062
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