Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a lipopolysaccharide (LPS)-injected mouse model of neurodegeneration and synaptic impairment. For this purpose, LPS was injected for two weeks on an alternate-day basis (250 µg/kg/i.p. for a total of seven doses), whil...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Badshah, Haroon, Ikram, Muhammad, Ali, Waqar, Ahmad, Sareer, Hahm, Jong Ryeal, Kim, Myeong Ok
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921022/
https://ncbi.nlm.nih.gov/pubmed/31717470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110719
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