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Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor. Stx2e targets endothelial cells of animal organs including the kidney harboring the Stx receptor glycosphingolipids (GSLs) globotriaosylcer...

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Publicat a:Microorganisms
Autors principals: Detzner, Johanna, Gloerfeld, Caroline, Pohlentz, Gottfried, Legros, Nadine, Humpf, Hans-Ulrich, Mellmann, Alexander, Karch, Helge, Müthing, Johannes
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920957/
https://ncbi.nlm.nih.gov/pubmed/31752441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms7110582
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