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Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher shelf temperature. We used 2-hydroxypropyl-betacyclodextrin (HPBCD) in combination with sucrose and poly...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Haeuser, Christina, Goldbach, Pierre, Huwyler, Joerg, Friess, Wolfgang, Allmendinger, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920930/
https://ncbi.nlm.nih.gov/pubmed/31744221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110616
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