SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its prote...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gassen, Nils C., Niemeyer, Daniela, Muth, Doreen, Corman, Victor M., Martinelli, Silvia, Gassen, Alwine, Hafner, Kathrin, Papies, Jan, Mösbauer, Kirstin, Zellner, Andreas, Zannas, Anthony S., Herrmann, Alexander, Holsboer, Florian, Brack-Werner, Ruth, Boshart, Michael, Müller-Myhsok, Bertram, Drosten, Christian, Müller, Marcel A., Rein, Theo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920372/
https://ncbi.nlm.nih.gov/pubmed/31852899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13659-4
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