Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1(+/−) mouse model

Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1(+/−) mice, a model of sporadic Parkinson’s disease. We found that the GM1 oligosaccharide, systemical...

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Argitaratua izan da:Sci Rep
Egile Nagusiak: Chiricozzi, Elena, Mauri, Laura, Lunghi, Giulia, Di Biase, Erika, Fazzari, Maria, Maggioni, Margherita, Valsecchi, Manuela, Prioni, Simona, Loberto, Nicoletta, Pomè, Diego Yuri, Ciampa, Maria Grazia, Fato, Pamela, Verlengia, Gianluca, Cattaneo, Stefano, Assini, Robert, Wu, Gusheng, Alselehdar, Samar, Ledeen, Robert W., Sonnino, Sandro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
https://ncbi.nlm.nih.gov/pubmed/31852959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55885-2
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