Flow-Cytometry Platform for Intracellular Detection of FVIII in Blood Cells: A New Tool to Assess Gene Therapy Efficiency for Hemophilia A

Detection of factor VIII (FVIII) in cells by flow cytometry is controversial, and no monoclonal fluorescent antibody is commercially available. In this study, we optimized such an assay and successfully used it as a platform to study the functional properties of phosphoglycerate kinase (PGK)-FVIII l...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Elnaggar, Muhammad, Al-Mohannadi, Anjud, Kizhakayil, Dhanya, Raynaud, Christophe Michel, Al-Mannai, Sharefa, Gentilcore, Giusy, Pavlovski, Igor, Sathappan, Abbirami, Van Panhuys, Nicholas, Borsotti, Chiara, Follenzi, Antonia, Grivel, Jean-Charles, Deola, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920166/
https://ncbi.nlm.nih.gov/pubmed/31886317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.003
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