A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells

Live-cell imaging of RNA has remained a challenge because of the lack of naturally fluorescent RNAs. Recently developed RNA aptamers that can light-up small fluorogenic dyes could overcome this limitation, but they still suffer from poor brightness and photostability. Here, we propose a concept of c...

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Udgivet i:Nat Chem Biol
Main Authors: Bouhedda, Farah, Fam, Kyong Tkhe, Collot, Mayeul, Autour, Alexis, Marzi, Stefano, Klymchenko, Andrey, Ryckelynck, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920041/
https://ncbi.nlm.nih.gov/pubmed/31636432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0381-8
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