Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its...

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Udgivet i:Cell Rep
Main Authors: Mills, Bradley N., Connolly, Kelli A., Ye, Jian, Murphy, Joseph D., Uccello, Taylor P., Han, Booyeon J., Zhao, Tony, Drage, Michael G., Murthy, Aditi, Qiu, Haoming, Patel, Ankit, Figueroa, Nathania M., Johnston, Carl J., Prieto, Peter A., Egilmez, Nejat K., Belt, Brian A., Lord, Edith M., Linehan, David C., Gerber, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919969/
https://ncbi.nlm.nih.gov/pubmed/31597100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.095
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