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NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

BACKGROUND: Human hepatocyte in vitro cell culture systems are important models for drug development and toxicology studies in the context of liver xenobiotic metabolism. Often, such culture systems are used to elucidate the biotransformation of xenobiotics or drugs and further investigate drug and...

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Bibliografski detalji
Izdano u:Clin Hemorheol Microcirc
Glavni autori: Schulz, Christian, Kammerer, Sarah, Küpper, Jan-Heiner
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918903/
https://ncbi.nlm.nih.gov/pubmed/31561354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CH-199226
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