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Stable expression of human cytochrome P450 2D6*10 in HepG2 cells

AIM: Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for < 2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to stu...

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Publicat a:World J Gastroenterol
Autors principals: Zhuge, Jian, Yu, Ying-Nian, Wu, Xiao-Dan
Format: Artigo
Idioma:Inglês
Publicat: Baishideng Publishing Group Inc 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717011/
https://ncbi.nlm.nih.gov/pubmed/14716830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v10.i2.234
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