Development of human brain organoids with functional vascular-like system

Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs), provide an excellent platform to study human brain development and diseases in complex 3D tissue. However, current hCOs lack microvasculature, resulting in limited oxygen and nutrient delivery to the inner-most parts o...

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Dades bibliogràfiques
Publicat a:Nat Methods
Autors principals: Cakir, Bilal, Xiang, Yangfei, Tanaka, Yoshiaki, Kural, Mehmet Hamdi, Parent, Maxime, Kang, Young-Jin, Chapeton, Kayley, Patterson, Benjamin, Yuan, Yifan, He, Chang-Shun, Raredon, Micha Sam Brickman, Dengelegi, Jake, Kim, Kun-Yong, Sun, Pingnan, Zhong, Mei, Lee, Sang-Ho, Patra, Prabir, Hyder, Fahmeed, Niklason, Laura E., Lee, Sang-Hun, Yoon, Young-sup, Park, In-Hyun
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918722/
https://ncbi.nlm.nih.gov/pubmed/31591580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0586-5
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