Development of human brain organoids with functional vascular-like system

Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs), provide an excellent platform to study human brain development and diseases in complex 3D tissue. However, current hCOs lack microvasculature, resulting in limited oxygen and nutrient delivery to the inner-most parts o...

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Publicado en:Nat Methods
Main Authors: Cakir, Bilal, Xiang, Yangfei, Tanaka, Yoshiaki, Kural, Mehmet Hamdi, Parent, Maxime, Kang, Young-Jin, Chapeton, Kayley, Patterson, Benjamin, Yuan, Yifan, He, Chang-Shun, Raredon, Micha Sam Brickman, Dengelegi, Jake, Kim, Kun-Yong, Sun, Pingnan, Zhong, Mei, Lee, Sang-Ho, Patra, Prabir, Hyder, Fahmeed, Niklason, Laura E., Lee, Sang-Hun, Yoon, Young-sup, Park, In-Hyun
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918722/
https://ncbi.nlm.nih.gov/pubmed/31591580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0586-5
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