Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation

BACKGROUND: There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act similarly to generate sphingomyelin (SM). We have undertaken the experiments rep...

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Udgivet i:Mol Med
Main Authors: Matsumoto, Goichi, Hashizume, Chieko, Watanabe, Ken, Taniguchi, Makoto, Okazaki, Toshiro
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918654/
https://ncbi.nlm.nih.gov/pubmed/31847800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0123-0
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