Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

BACKGROUND: Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology of NPC is poorly defined. In that regard, neuroinflammation occurs early in...

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Publicat a:J Neuroinflammation
Autors principals: Shin, Samuel D., Shin, Alexandra, Mayagoitia, Karina, Siebold, Lorraine, Rubini, Marsilio, Wilson, Christopher G., Bellinger, Denise L., Soriano, Salvador
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918596/
https://ncbi.nlm.nih.gov/pubmed/31847862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1663-5
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