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Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

BACKGROUND: Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology of NPC is poorly defined. In that regard, neuroinflammation occurs early in...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Shin, Samuel D., Shin, Alexandra, Mayagoitia, Karina, Siebold, Lorraine, Rubini, Marsilio, Wilson, Christopher G., Bellinger, Denise L., Soriano, Salvador
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918596/
https://ncbi.nlm.nih.gov/pubmed/31847862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1663-5
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