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Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions

Human liver microsomes (HLM) and human liver S9 fractions (HLS9) are commonly used to study drug metabolism in vitro. However, a quantitative comparison of HLM and HLS9 proteomes is lacking, resulting in the arbitrary selection of one hepatic preparation over another and in difficulties with data in...

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Détails bibliographiques
Publié dans:Drug Metab Dispos
Auteurs principaux: Wang, Xinwen, He, Bing, Shi, Jian, Li, Qian, Zhu, Hao-Jie
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918043/
https://ncbi.nlm.nih.gov/pubmed/31699809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089235
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