GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A

Excessive expression of subunit 1 of GIRK1 in ER(+) breast tumors is associated with reduced survival times and increased lymph node metastasis in patients. To investigate possible tumor-initiating properties, benign MCF10A and malign MCF7 mammary epithelial cells were engineered to overexpress GIRK...

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Publicat a:Sci Rep
Autors principals: Schratter, Gebhard, Scheruebel, Susanne, Langthaler, Sonja, Ester, Katja, Pelzmann, Brigitte, Ghaffari-Tabrizi-Wizsy, Nassim, Rezania, Simin, Gorischek, Astrid, Platzer, Dieter, Zorn-Pauly, Klaus, Ahammer, Helmut, Prokesch, Andreas, Stanzer, Stefanie, Devaney, Trevor T. J., Schmidt, Kurt, Jahn, Stephan W., Prassl, Ruth, Bauernhofer, Thomas, Schreibmayer, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917815/
https://ncbi.nlm.nih.gov/pubmed/31848385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55683-w
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