Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway

A number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identificatio...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Simão-Gurge, Raquel M., Wunderlich, Gerhard, Cricco, Julia A., Cubillos, Eliana F. Galindo, Doménech-Carbó, Antonio, Cebrián-Torrejón, Gerardo, Almeida, Fernando G., Cirulli, Brenda A., Katzin, Alejandro M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917786/
https://ncbi.nlm.nih.gov/pubmed/31848371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55506-y
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