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Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy

BACKGROUND: Congenital obstructive nephropathy is the main cause of end-stage renal disease in infants and children. Renal insufficiency is due to impaired growth and maturation in the developing kidney with obstruction. Congenital obstructive nephropathy leads to cytokine mediated inflammation and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gasparitsch, Mojca, Schieber, Alexandra, Schaubeck, Teresa, Keller, Ursula, Cattaruzza, Marco, Lange-Sperandio, Bärbel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917291/
https://ncbi.nlm.nih.gov/pubmed/31846485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226675
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