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Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is the predominant and most lethal histological type of epithelial ovarian cancer. During the last few years, several new treatment options with PARP inhibitors have emerged. The FDA has approved the PARP inhibitor olaparib (Lynparza™) as maintenance treatmen...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sahin, Irem Durmaz, Jönsson, Jenny-Maria, Hedenfalk, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916751/
https://ncbi.nlm.nih.gov/pubmed/31857852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27363
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