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Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control

The protein quality control machinery of the endoplasmic reticulum (ERQC) ensures that client proteins are properly folded. ERQC substrates may be recognized as nonnative by the presence of exposed hydrophobic surfaces, free thiols, or processed N-glycans. How these features dictate which ERQC pathw...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Adams, Benjamin M., Ke, Haiping, Gierasch, Lila M., Gershenson, Anne, Hebert, Daniel N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916506/
https://ncbi.nlm.nih.gov/pubmed/31662433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010450
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