Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control

The protein quality control machinery of the endoplasmic reticulum (ERQC) ensures that client proteins are properly folded. ERQC substrates may be recognized as nonnative by the presence of exposed hydrophobic surfaces, free thiols, or processed N-glycans. How these features dictate which ERQC pathw...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Adams, Benjamin M., Ke, Haiping, Gierasch, Lila M., Gershenson, Anne, Hebert, Daniel N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916506/
https://ncbi.nlm.nih.gov/pubmed/31662433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010450
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