Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells

Cytoplasmic dsRNA is recognized by RNA helicase RIG-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), triggering induction of the innate immune response via the mitochondrial antiviral signaling protein (MAVS). In contrast, extracellular dsRNA is internalized into endosomes and rec...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Guanming, Kouwaki, Takahisa, Mugikura, Kazuki, Okamoto, Masaaki, Takaki, Hiromi, Funami, Kenji, Seya, Tsukasa, Oshiumi, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916484/
https://ncbi.nlm.nih.gov/pubmed/31615841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009783
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