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Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau's N-terminal domain
Tau is an intrinsically disordered, microtubule-associated protein that has a role in regulating microtubule dynamics. Despite intensive research, the molecular mechanisms of Tau-mediated microtubule polymerization are poorly understood. Here we used single-molecule fluorescence to investigate the r...
Gardado en:
| Publicado en: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6916478/ https://ncbi.nlm.nih.gov/pubmed/31699899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010172 |
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