Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

Translocator protein (TSPO) expression is increased in activated glia, and has been used as a marker of neuroinflammation in PET imaging. However, the extent to which TSPO upregulation reflects a pro‐ or anti‐inflammatory phenotype remains unclear. Our aim was to determine whether TSPO upregulation...

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Vydáno v:Glia
Hlavní autoři: Pannell, Maria, Economopoulos, Vasiliki, Wilson, Thomas C., Kersemans, Veerle, Isenegger, Patrick G., Larkin, James R., Smart, Sean, Gilchrist, Stuart, Gouverneur, Véronique, Sibson, Nicola R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916298/
https://ncbi.nlm.nih.gov/pubmed/31479168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23716
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