Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial

In adults with X‐linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25‐dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. Osteomalacia is associated with poor bone quality causing atraumatic fractures, p...

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Bibliografische gegevens
Gepubliceerd in:J Bone Miner Res
Hoofdauteurs: Insogna, Karl L, Rauch, Frank, Kamenický, Peter, Ito, Nobuaki, Kubota, Takuo, Nakamura, Akie, Zhang, Lin, Mealiffe, Matt, San Martin, Javier, Portale, Anthony A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2019
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Clinical Trials
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916280/
https://ncbi.nlm.nih.gov/pubmed/31369697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3843
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