Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial

In adults with X‐linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25‐dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. Osteomalacia is associated with poor bone quality causing atraumatic fractures, p...

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Опубликовано в: :J Bone Miner Res
Главные авторы: Insogna, Karl L, Rauch, Frank, Kamenický, Peter, Ito, Nobuaki, Kubota, Takuo, Nakamura, Akie, Zhang, Lin, Mealiffe, Matt, San Martin, Javier, Portale, Anthony A
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Inc. 2019
Предметы:
Clinical Trials
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916280/
https://ncbi.nlm.nih.gov/pubmed/31369697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3843
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