Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X‐Linked Hypophosphatemia: A Phase 3, Single‐Arm, International Trial

In adults with X‐linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25‐dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. Osteomalacia is associated with poor bone quality causing atraumatic fractures, p...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Insogna, Karl L, Rauch, Frank, Kamenický, Peter, Ito, Nobuaki, Kubota, Takuo, Nakamura, Akie, Zhang, Lin, Mealiffe, Matt, San Martin, Javier, Portale, Anthony A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916280/
https://ncbi.nlm.nih.gov/pubmed/31369697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3843
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