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Crossing fitness valleys via double substitutions within codons
BACKGROUND: Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N substitutions are affected by purifying selection that elimin...
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| Publicado no: | BMC Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6916188/ https://ncbi.nlm.nih.gov/pubmed/31842858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-019-0727-4 |
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