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Considering the Role of Murine Double Minute 2 in the Cardiovascular System?
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53-independent oncogenic function. These studies have con...
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| Pubblicato in: | Front Cell Dev Biol |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6916148/ https://ncbi.nlm.nih.gov/pubmed/31921839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00320 |
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