Evaluation of off‐target effects of gapmer antisense oligonucleotides using human cells

Antisense oligonucleotide (ASO) has the potential to induce off‐target effects due to complementary binding between the ASO and unintended RNA with a sequence similar to the target RNA. Conventional animal studies cannot be used to assess toxicity induced by off‐target effects because of differences...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Genes Cells
Asıl Yazarlar: Yoshida, Tokuyuki, Naito, Yuki, Yasuhara, Hidenori, Sasaki, Kiyomi, Kawaji, Hideya, Kawai, Jun, Naito, Mikihiko, Okuda, Haruhiro, Obika, Satoshi, Inoue, Takao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915909/
https://ncbi.nlm.nih.gov/pubmed/31637814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gtc.12730
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