GPR56 drives colorectal tumor growth and promotes drug resistance through upregulation of MDR1 expression via a RhoA-mediated mechanism

Drug resistance continues to be a major obstacle of effective therapy for colorectal cancer, leading to tumor relapse or treatment failure. Cancer stem cells (CSCs) or tumor-initiating cells are a subpopulation of tumor cells which retain the capacity for self-renewal and are suggested to be implica...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Res
Huvudupphovsmän: Zhang, Sheng, Chatterjee, Treena, Godoy, Carla, Wu, Ling, Liu, Qingyun J., Carmon, Kendra S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913243/
https://ncbi.nlm.nih.gov/pubmed/31444231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0436
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